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While further validation in independent cohorts is required, this design aligns with emerging best-practice recommendations for robust metabolomics studies 77,78

We combine orthogonal analytical approaches to confirm composition, assess purity, and provide structure-relevant evidence that supports metabolite assignment, method development, or repeat synthesis decisions

We observed an increase in SenTraGor-positive cells (as assessed by GL13 or GFL16 staining) in palbociclib-treated tumours

Inhibition of glutathione disulfide reductase by glutathione [PMID: 1898023] Laboratory literature summary: Inhibition of glutathione disulfide reductase by glutathione